Catalytic asymmetric Catellani-type reaction: A powerful tool for axial chirality construction

Catalytic asymmetric desymmetrization of N-arylmaleimides: efficient construction of both atom chirality and axial chirality.

The catalytic asymmetric Michael addition/desymmetrization reaction of N-(2-t-butylphenyl)maleimides with unprotected 3-substituted-2-oxindoles was successfully realized using a chiral N,N'-dioxide-Sc(III) complex, leading to succinimides with two kinds of stereogenic elements—atom chirality and axial chirality—in up to 99% yield, 99% ee and >19 : 1 d.r.

Asymmetric aldol reaction via memory of chirality.

Asymmetric aldol reactions of α-amino acid derivatives via memory of chirality were developed. Chiral oxazolidones with contiguous tetra- and trisubstituted chiral centers were obtained in 78-94% ee by the asymmetric aldol reaction followed by intramolecular acylation.

Pd asymmetric allylic alkylation (AAA). A powerful synthetic tool.

Palladium catalyzed asymmetric allylic alkylations represent a challenging problem because the mechanism of the reaction places the chiral environment distal to the bond breaking or making events responsible for the asymmetric induction. Furthermore, unlike virtually every other asymmetric process, many strategies can be employed for introduction of asymmetry and many different types of bonds c...

Asymmetric Reaction Using Molecular Chirality Controlled by Spontaneous Crystallization

Polymerase Chain Reaction: a Powerful Diagnostic and Research Tool

To fully understand cellular processes, scientists often examine events at the level of nucleic acids and protein molecules. These studies are complicated by the fact that cells have miniscule amounts of molecules of interest which are too small to be seen. So we require molecular tools to visualize these molecules. Polymerase chain reaction is one such technique widely used in molecular biolog...